|
KMID : 1044520190820040348
|
|
Tuberculosis and Respiratory Diseases
2019 Volume.82 No. 4 p.348 ~ p.356
|
|
|
Long-Term Outcomes of Adult Lung Transplantation Recipients: A Single-Center Experience in South Korea
|
|
Jo Kyung-Wook
Hong Sang-Bum
Kim Dong-Kwan
Jung Sung-Ho
Kim Hyeong-Ryul
Choi Se-Hoon
Lee Geun-Dong
Lee Sang-Oh
Do Kyung-Hyun
Chae Eun-Jin
Choi In-Cheol
Choi Dae-Kee
Kim In-Ok
Park Seung-Il
Shim Tae-Sun
|
|
|
Abstract
|
|
|
Background: Recently, the number of lung transplants in South Korea has increased. However, the long-term outcome data is limited. In this study, we aimed to investigate the long-term outcomes of adult lung transplantation recipients.
Methods: Among the patients that underwent lung transplantation at a tertiary referral center in South Korea between 2008 and 2017, adults patient who underwent deceased-donor lung transplantation with available follow-up data were enrolled. Their medical records were retrospectively reviewed.
Results: Through eligibility screening, we identified 60 adult patients that underwent lung (n=51) or heart-lung transplantation (n=9) during the observation period. Idiopathic pulmonary fibrosis (46.7%, 28/60) was the most frequent cause of lung transplantation. For all the 60 patients, the median follow-up duration for post-transplantation was 2.6 years (range, 0.01?7.6). During the post-transplantation follow-up period, 19 patients (31.7%) died at a median duration of 194 days. The survival rates were 75.5%, 67.6%, and 61.8% at 1 year, 3 years, and 5 years, respectively. Out of the 60 patients, 8 (13.3%) were diagnosed with chronic lung allograft dysfunction (CLAD), after a mean duration of 3.3±2.8 years post-transplantation. The CLAD development rate was 0%, 17.7%, and 25.8% at 1 year, 3 years, and 5 years, respectively. The most common newly developed post-transplantation comorbidity was the chronic kidney disease (CKD; 54.0%), followed by diabetes mellitus (25.9%).
Conclusion: Among the adult lung transplantation recipients at a South Korea tertiary referral center, the long-term survival rates were favorable. The proportion of patients who developed CLAD was not substantial. CKD was the most common post-transplantation comorbidity.
|
|
|
KEYWORD
|
|
|
Lung Transplantation, Survival, Chronic Lung Allograft Dysfunction, Chronic Kidney Disease
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|